Sorbifer Durules – antianemic combined drug, which combines iron sulfate with ascorbic acid. The pronounced therapeutic effect of the drug in anemia (anemia) is provided precisely by the combined action of its constituents: iron sulfate compensates for iron deficiency in the body, and vitamin C increases its absorption in the digestive tract.
Durules – a special technology for the preparation of the drug, which allows iron ions to be evenly and gradually released in the intestine not by the action of digestive juices, but as a result of peristalsis (wave-like movements of the intestinal walls).
Such a gradual (over 6 hours) release of iron ions prevents the creation of an increased number of them in the digestive organs and prevents the irritating action of iron ions on the mucous membrane of the digestive tract.
The absorption of the drug in the small intestine, thanks to this technology, is high, 30% higher than that of others. iron preparations. It is ascorbic acid that increases its absorbability.
Forms of release
Instructions for use Sorbifer Durules
Indications for use
It is advisable to use Sorbifer Durules only in the case of iron deficiency anemia. With anemia caused by another reason, the drug should not be prescribed.
Before treatment, the iron-binding activity and the level of iron in the blood are determined.
one. High iron content:
- hemochromatosis (hereditary iron metabolism)
- hemosiderosis (a disease associated with enhanced breakdown of red blood cells).
2 Diseases associated with impaired iron absorption:
- aplastic anemia (oppression of bone marrow hematopoiesis)
- hemolytic anemia (associated with increased erythrocyte destruction)
- lead anemia (occurs when lead poisoning)
- sideroblastic anemia (the level of iron is sufficient, but the body cannot use it)
four. Condition after removal of the stomach
five. Age 12 years
6 The narrowing of the lumen of the esophagus or other parts of the digestive tract
7 Intolerance to any component of the drug.
Apply Sorbifer with caution should be taken with Crohn’s disease (inflammatory process of various parts of the digestive tract), diverticulitis, peptic ulcer disease (duodenal ulcer, stomach or large intestine), inflammation of the small intestine (enteritis).
During treatment with Sorbifer, vomiting, abdominal pain, nausea, unpleasant taste in the mouth, impaired stool (constipation or diarrhea), loss of appetite may appear. These manifestations may increase with increasing doses up to 400 mg.
It is rarely observed such adverse reactions as ulceration of the esophagus, narrowing of the esophagus, headache, fever of the skin, weakness, dizziness, allergic skin manifestations (rash, pruritus).
How to take sorbifer?
The pill should be swallowed whole, not chewed, half an hour before meals, the tablet should be washed down with water (at least 100 ml).
Against the background of treatment with Sorbifer, as well as other iron-containing drugs, black color of fecal masses is noted. Her appearance should not cause concern to the patient.
Egg yolk, tea, dairy products reduce absorption of Sorbifer.
The usual therapeutic dose of Sorbifer is 1 tablet or 100 mg 2 times a day. With the appearance of side effects, the dose of the drug is reduced to 1 tablet per day.
Depending on the severity of anemia, the dose may be increased to 300-400 mg per day (3-4 tablets) in 2 doses.
The duration of the course of treatment is determined by the doctor. During treatment, a general blood test and serum iron levels are monitored. After the normalization of indicators usually prolong the treatment for 2 months to create a reserve of iron in the body. In severe anemia, the course can be extended up to 3-6 months.
The preventive and maintenance dose is 100 mg (1 tablet) per day.
The simultaneous use of Sorbifer with other iron preparations should be avoided (to avoid overdose). In case of overdose, the following signs may appear: vomiting, abdominal pain, diarrhea with blood, weakness, pallor of the skin, low blood pressure, weak pulse, palpitations, fever, the smell of acetone from the mouth. In severe cases of overdose, renal and hepatic failure, decreased blood sugar, seizures, and loss of consciousness may occur.
Sorbifer for children
Clinical data on the use of Sorbifer to children under 12 years of age are not available.
Sorbifer during pregnancy
During pregnancy, almost all women show varying degrees of severity of iron deficiency and the development of anemia, which is dangerous for both women and children. Therefore, during the II and III trimesters of pregnancy, with prophylactic purposes, iron preparations are prescribed to all pregnant women.
The drug of choice from the number of iron-containing drugs for pregnant women is most often Sorbifer Durules, which can provide a fairly rapid increase in the level of iron in a woman’s body. For prophylactic purposes, Sorbifer is administered 1 tablet per day.
In the case of anemia in a pregnant woman with a therapeutic purpose, Sorbifer is prescribed 1 tablet 1-2 times a day (depending on the severity of anemia). As a rule, in the third trimester of pregnancy and for the period of breastfeeding, Sorbifer is prescribed in a daily dose of 200 mg divided into 2 doses.
The duration of the course of treatment is determined by the doctor, taking into account the hemoglobin level. In some cases, after recovery, treatment with Sorbifer is extended for another 2 months (to replenish iron stores).
Sorbifer Drug Interactions
- The absorption of both drugs decreases with the simultaneous administration of sorbifer and D-penicillamine or tetracycline antibiotics.
- Reduce the absorption of iron antacids (drugs containing calcium, magnesium, aluminum).
- Sorbifer Durules can reduce the absorption of clodronate, enoxacin, methyldopa, levodopa, grepafloxacin, levofloxacin and thyroid hormones (thyroid gland).
- The use of Sorbifer at the same time as Ofloxacin, Norfloxacin, Doxycycline, Ciprofloxacin is not recommended.
If it is necessary to use any of the listed drugs, a 2-hour interval should be provided between taking Sorbifer and this drug. If necessary, the use of tetracyclines – the interval must be at least 3 hours.
Analogues of the drug Sorbifer Durules on the active substance are Ferropleks, Fenyuls 100.
Analogs of the drug for therapeutic action: Aktiferrin compositum, Biofer, Gemofer, Venofer, Gino Tardiferon, Totem, Ferretab, Ferrograddumet, Ferrinat, Heferol, Ferronal, etc.
Many women who took Sorbifer during pregnancy, note a good therapeutic effect of the drug. This is also evidenced by reviews of patients treated for iron deficiency anemia.
A number of reviews described a decrease in hemoglobin as early as a month after stopping treatment (the drug was discontinued immediately after normalization of general blood counts). This indicates not a lack of the drug, but non-compliance with the instructions for its use (it is recommended to achieve the effect of treatment not to stop taking the medicine, but to switch to maintenance doses).
In many responses marked pronounced side effects from the digestive organs in several cases, these manifestations have caused the drug to be canceled.
In many reviews, as a disadvantage of the drug indicated its high price.
The price of the drug in various cities and pharmacies – 500-700 rubles.