Suprax represents antibiotic from the group cephalosporins III generation intended for oral administration. The drug is used to treat bacterial infections of various organs, such as infectious and inflammatory diseases of the respiratory tract (pharyngitis, tonsillitis, sinusitis, bronchitis), urinary and biliary tract (cystitis, pyelonephritis, cholecystitis), skin and soft tissues (phlegmons, abscesses, furuncles etc.), as well as otitis media, osteomyelitis, endometritis, Lyme disease, cervical gonorrhea, urethra.
Varieties, names, release forms and composition
Currently, antibiotic Supraks is available in two varieties, which are called Suprax and Supraks Solutab. In fact, these two types of drug differ from each other only in the names and forms of release, and there are no more differences between them, since they contain the same active substances, and they also have the same indications, contraindications and rules of application. That is why Supraks and Supraks Solutab are often combined at the household level under one common name "Suprax". In the further text of the article we will do the same, under the general name "Suprax" we will mean both varieties of the same drug. Specify the specific dosage form and its name will only become in the case when it will be necessary to focus on any features of these varieties.
In general, it can be conditionally assumed that different names were given to different medicinal forms of the same drug for commercial reasons. From the point of view of commercial interests, it is more convenient for manufacturing firms to sell the same drug under different names.
So, Supraks is available in three dosage forms:
- Dispersible tablets (under the commercial name Supraks Solyutab)
- Capsules for oral administration (under the commercial name Supraks)
- Granules for the preparation of suspensions for oral administration (under the commercial name Supraks).
Dispersible tablets (absorbable) sold under the name "Supraks Solutab", they have an oblong shape, are supplied with a risk on both sides, are painted in a pale orange color and have a strawberry smell. Available in packs of 1, 5, 7 or 10 tablets.
Capsules issued under the name "Suprax"They are oblong cylinders consisting of a white body and a purple lid. On the surface of the capsules there is an inscription "H808"applied with food ink. Inside the capsules contains a mixture of powder and small granules, painted in yellowish-white color. Capsules are available in packs of 6 pieces.
Granules for suspension for oral use are issued under the name "Suprax", they are small balls, painted in white or cream color. The finished suspension obtained after dissolving the granules in water is colored white or cream-colored and has a sweet strawberry aroma. The granules are available in dark glass bottles, to which a dosing spoon or dosing syringe is attached to measure the required amount of the finished suspension. In the vials are 30.3 – 35.0 g of granules, which, when dissolved, give a suspension with a concentration of the active substance of 100 mg per 5 ml, or 20 mg per 1 ml.
The composition of all Supraksa dosage forms as the active component includes the same substance – cefixime. Cefixime enters the finished medicine not in pure form, but in the form of salt – cefixime trihydrate, because it ensures its passage through the corrosive environment of the stomach intact, and the release of the active substance in the intestine, from where it is absorbed into the bloodstream.
Each tablet contains 447.7 mg of cefixime trihydrate, and the capsule contains 466 mg, which corresponds to 400 mg of pure cefixime. Accordingly, both tablets and Suprax capsules have the same dosage – 400 mg. Because of this, they are often at the everyday level called Suprax 400. Earlier commercially available capsules with a dosage of the active substance 200 mg, but at present there are none.
Granules of one vial contain 1.402 g of cefixime trihydrate, which corresponds to 1.2 g of pure cefixime. Such an amount of antibiotic allows you to create a concentration of the active substance cefixime in the finished solution of 100 mg per 5 ml (20 mg per 1 ml). The amount of pure cefixime in 5 ml of the prepared solution (100 mg) corresponds to 116.83 mg of cefixime trihydrate.
The composition of the excipients of tablets, capsules and granules is given in the table:
Suprax has an antibacterial effect, destroying pathogenic bacteria. It is a broad-spectrum antibiotic because it is detrimental to a large number of different types of pathogenic bacteria. Suprax’s destructive effect on bacteria is due to its ability to disrupt the synthesis of the cell wall of pathogenic microbes, without which they simply cannot exist. Along with the destructiveness of Supraksa for bacteria, the drug is at the same time safe for the human body, therefore it can be used to treat children from the age of six months.
Due to its antibacterial action, Suprax leads to recovery from infectious diseases of various organs and systems, if they are caused by bacteria that are sensitive to the effect of the antibiotic.
Suprax is resistant to beta-lactamase – special substances produced by bacteria to protect against antibiotics. Many antibiotics are unstable to the action of beta-lactamase, ineffective against bacteria that produce these substances. Therefore, Suprax is considered a highly effective antibiotic to which resistance of beta-lactamase-producing bacteria does not develop.
Suprax has a detrimental effect on the following types of pathogenic and conditionally pathogenic bacteria:
- Citrobacter amalonaticus
- Citrobacter diversus
- Escherichia coli
- Haemophilus influenzae
- Haemophilus parainfluenzae
- Klebsiella pneumoniae
- Klebsiella oxytoca
- Moraxella (Branhamella) catarrhalis
- Morganella morganii
- Neisseria gonorrheae
- Proteus vulgaris
- Proteus mirabilis
- Pasteurella multocida
- Providencia spp.
- Streptococcus agalactiae
- Streptococcus pneumoniae
- Streptococcus pyogenes
- Salmonella spp.
- Shigella spp.
- Serratia marcescens.
The following types of bacteria are resistant to the action of Supraks:
- Bacteroides fragilis
- Clostridium spp.
- Enterococcus (Streptococcus) Group D
- Enterobacter spp.
- Listeria monocytogenes
- Pseudomonas spp.
- Staphylococcus spp.
The effectiveness of Supraksa once a day for various diseases, according to research data from clinical pharmacologists in Hungary, is as follows:
- Pneumonia (pneumonia) – 90.9%
- Tonsillopharyngitis – 92.6%
- Exacerbation of chronic bronchitis – 72.2%
- Sinusitis in children – 97.8%
- Otitis media in children – 96.0%
- Urinary tract infections – 95.0%.
40 – 50% of the total accepted dose of Suprax is absorbed into the systemic circulation, and this amount does not depend on food intake. Displays antibiotic during the day in an amount of about 60% of the dose. At the same time 50% is excreted unchanged in the urine, and 10% is excreted in the bile. The remaining 40% of the dose taken out of the body within a few days.
Indications for use
Instructions for use
Suprax suspension – instructions for use
Suprax is produced and sold in the form of granules intended for the preparation of a suspension, which is taken internally. The finished suspension can be used for the treatment of adults and children over six months. For young children, it is the suspension is the optimal dosage form of Supraksa.
Before use, the granules in the vial should be dissolved to form a suspension. Dissolve the granules should be only when there is a need to take Supraksa, because the finished suspension is stored only for two weeks (14 days). After two weeks, the suspension, even if it has not been fully consumed, must be discarded. And if it is necessary for any reason to continue taking Supraks for more than 14 days, you will have to make a new suspension, spreading the granules in a vial with water. In the form of granules, the drug is stored for a long time, and can be used until the expiration date indicated on the package.
How to dilute the suspension Supraks?
To prepare the suspension should turn the bottle upside down and shake its contents well. Then it is necessary to open the cap and add 40 ml of cooled boiled water to the bottle in two stages. That is, you should first pour 20 ml of water into the vial, wait a little, and then pour another 20 ml. After that, it is necessary to shake the contents of the bottle well and place it for 5 minutes on a table or other horizontal surface so that the granules are well dissolved, and the foam formed during mixing has settled. When the foam settles, you need to carefully see whether the level of the liquid reaches the mark in the form of an arrow on the label of the bottle. If the level of the liquid does not reach the arrow, then it is necessary to pour a little more water into the vial so that it reaches the mark. After this suspension is considered prepared and ready for use.
You can pour water into the vial without measuring 40 ml beforehand, but simply bringing its level to the mark. However, it is possible to do this only if a person has experience in filling any containers to the marks applied to them. After all, if water is poured above the level of the label, the solution will have to be thrown away, since its concentration will be incorrect and unsuitable for treatment.
The most convenient way is to measure the required amount of water to dilute the suspension or pour it directly into the vial using a standard 20-25 ml syringe.
Ready diluted suspension should be stored at a temperature of 15 – 25 o С no longer than 14 days. During storage, freezing of the suspension must not be allowed. If the suspension is frozen, then it should be discarded, and to continue treatment, prepare a new one from another vial.
How to take a suspension?
After dilution, the suspension can be applied for 14 days. Before each use, the vial of suspension should be shaken well. For measuring the required amount of suspension, you can use only the dosing spoon attached to the kit or the dosing syringe. Do not use other tools, devices and containers (syringes, spoons, pipettes, etc.) to measure Supraksa suspension.
Suspension Supraks in the right quantity should be swallowed and, if necessary, drink a small amount of water (for example, if the subjectively unpleasant taste remains in the mouth). Drink the suspension should be directly from the dosing spoon or dosing syringe, not pouring the drug into other containers. After the suspension has been drunk from the spoon or syringe, they should be washed with running water and detergent. Supraks suspension can be taken regardless of the meal, that is, at any convenient time.
In various diseases for which Supraksa is indicated, the drug is used in the same dosage, which is determined only by the person’s age, and does not depend on the type, location and nature of the infection. Thus, adults and adolescents over 12 years old with a body weight of more than 50 kg should take Suprax 200 mg (10 ml of suspension) twice a day, or 400 mg (20 ml of suspension) once a day.
For children aged 6 months – 12 years, the dosage of the suspension is calculated individually, depending on body weight, based on the ratio: 8 mg per 1 kg of body weight per day. The calculated dosage can be given to the child completely once a day, or divided in half into two doses per day. For example, if a child’s body weight is 10 kg, the Suprax dosage for it is 8 mg * 10 kg = 80 mg. Next, we calculate how many milliliters of the suspension contains 80 mg of the active substance. It is easy to calculate, knowing that in 1 ml of the suspension contains 20 mg of the active substance. This means that the amount of mg calculated by the child’s body weight should be divided by 20, and the final number will be the number of milliliters of suspension that should be given to the baby. In our example, 80 mg corresponds to 4 ml of suspension (in 1 ml of suspension 20 mg, then 80 mg is contained in 80 mg / 20 mg = 4 ml). This means that a 10 kg child should be given Suprax 4 ml once a day, or 2 ml twice a day.
On average, for children aged 6–12 months, the daily dosage of the suspension is 2.5–4 ml, for children 2–4 years old — 5 ml, for children 5–11 years old, 6–10 ml. The daily dosage can be given at once, or divided in half into two doses per day.
Suprax dosage is halved for children and adults who are on peritoneal dialysis or have kidney disease with a QA (creatinine clearance) of less than 20 ml / min. Children and adults who are on hemodialysis or suffering from kidney disease with a CC (creatinine clearance) of 21–60 ml / min, reduce the dosage of Suprax by 25% (that is, by 1/4).
The duration of Suprax use is 7–10 days, but for infections caused by Streptococcus pyogenes (pyogenic streptococcus) – at least 10 days, and optimally – 14 days. It is impossible to take Suprax for less than 7 days, as this can lead to incomplete healing and the formation of a variety of bacteria resistant to the antibiotic. And this, in turn, will lead to the fact that after some time the undertreated disease will definitely worsen again, but Suprax and other antibiotics of the cephalosporin group will be ineffective due to the fact that the bacteria have become resistant to the drug. In such a situation, it is necessary to use other, even stronger antibiotics.
For treatment of uncomplicated gonorrhea, it is enough to take 400 mg of Suprax (20 ml of suspension) only once.
Instructions for use Supraks suspension for children
Children aged 6 months – 12 years Supraks give only in the form of a suspension. Tablets and capsules may be given only to children over 12 years old.
For children under 12 years old, Supraksa dosage is calculated individually, by body weight, based on the ratio: 8 mg per 1 kg of body weight per day. The calculated daily dosage is given to the child in full once a day, or divided in half into two doses per day. The dosage of the drug is the same for various diseases, and depends only on the body weight of the child. Supraksa dosage does not change depending on the nature, location or severity of the infectious disease.
The duration of Suprax therapy is also the same for various diseases, and is 7 to 10 days. Only infections caused by Streptococcus pyogenes (pyogenic streptococcus) require the use of the drug for at least 10 days, and optimally for two weeks. And the treatment of uncomplicated gonorrhea requires taking Supraksa in the daily dosage only once. It is impossible to take Suprax for less than 7 days, as this may provoke the development of resistance to the antibiotic in bacteria. In this case, when the infection worsens, the Suprax will already be useless, and stronger and more severe antibiotics will have to be applied.
The usual dosage of Suprax is halved for children undergoing peritoneal dialysis or suffering from kidney disease with a CK (creatinine clearance) of less than 20 ml / min. For children on hemodialysis or suffering from kidney disease with a CC (creatinine clearance) of 21–60 ml / min, the usual dosage of Suprax is reduced by 25% (that is, 1/4).
Consider the example of the calculation of the dosage of Supraksa for children by body weight. For example, a child weighs 15 kg. This means that the daily dose of the drug for it is 8 mg * 15 kg = 120 mg. Now it is necessary to calculate how many milliliters of the suspension contain the 120 mg of active substance. This is easy to do, knowing that 1 ml of the suspension contains 20 mg of the active substance. So, you need to divide the milligrams calculated by weight into 20, and get the number of milliliters of the suspension that contains these milligrams. In our example, 120 mg should be divided into 20 mg, and get 120 mg / 20 mg = 6 ml. That is, the daily dosage of Supraksa for a child weighing 15 kg is 120 mg, which corresponds to 6 ml of suspension. You can give the drug once a day all 6 ml at once, or twice a day for 3 ml.
Measure the right amount of suspension should only be attached dosing spoon or dosing syringe. Do not use any other devices for dosing the drug. It should be aware that the dosing syringe allows you to measure the suspension more accurately than the dosing spoon.
For the convenience of parents, we give below a table with suspensions for children with different body weights, which are valid when using a dosing spoon. This means that if you bought a bottle with a dosing spoon, you can not calculate the dose of the drug yourself, but use the ready-made calculated dosages given in the table. However, it should be remembered that the dosages given in the table below are valid only for vials with a dosing spoon. For vials with a dosing syringe, they are different, and are listed separately:
Also for the convenience of parents, we give below a table with suspensions for children with different body weights, which are valid when using a dosing syringe. This means that if you bought a bottle with a dosing syringe, you can not calculate the dose of the drug yourself, but use the one already calculated and shown in the table below. It should be remembered that the dosages in the table below are valid only for the dosing syringe, and for the dosing spoon they are different, and are listed in the table above.
Supraks 400 (capsules) – instructions for use
The drug Supraks in capsule form can be used to treat adults and adolescents over 12 years old with a body weight of more than 50 kg. This means that adults over the age of 18 can use the drug without restriction, and adolescents over the age of 12 can take Suprax in capsule form only if their body weight is more than 50 kg. If the weight of a teenager is less than 50 kg, then he cannot take Supraks in capsules, even if he is older than 12 years. This restriction on body weight affects adolescents aged 12–18 years.
Children under 12 years old, as well as people who are on peritoneal hemodialysis or suffering from renal impairment with creatinine clearance (CK) of less than 60 ml / min, should not use Suprax in the form of capsules. Such people should take Supraks in the form of a suspension or dispersible tablets.
Capsules should be swallowed whole, without opening and emptying their contents, but with a sufficient amount of water (at least half a glass). Supraks capsules can be taken regardless of the meal, at any convenient time for a person. During the course of treatment, it is advisable to take the drug every day at about the same time.
Supraksa dosage is the same for the treatment of infectious diseases of various organs. Both adults and adolescents are prescribed 400 mg (1 capsule) once a day.
The duration of therapy is determined by the type of pathogenic microbe that provoked an infectious disease. So, with uncomplicated gonorrhea, the course of therapy consists of a single dose of Suprax at a dose of 400 mg. That is, for the treatment of gonorrhea, it is enough to take only one capsule of Supraks once. For infections provoked by Streptococcus pyogenes, the duration of therapy should be at least 10 days, and optimally – 14 days. For all other infections, the course of treatment with Suprax is 7 to 10 days.
It is impossible to take Suprax for less than 7 days, as this can lead to incomplete destruction of bacteria and their acquisition of antibiotic resistance. And this means that the next time Supraks will be ineffective, and it will be necessary to select other, even stronger antibiotics.
Suprax Solutab tablets – instructions for use
Tablets are intended for use by adults over 18 years of age and children whose body weight has reached at least 25 kg. This means that adults over the age of 18 can use Supraks Solutab freely, and tablets can be given to children if their weight is 25 kg or more, regardless of their age.
Tablets should be taken orally, swallowing whole and squeezed with a sufficient amount of non-carbonated water (100 ml is enough). If for any reason it is difficult to swallow the tablet completely, it must be dissolved in water and the resulting suspension should be drunk. You should not try to break, chew, chew or grind tablets Supraks Solyutab other ways. For washing and dissolving tablets Supraks Solyutab you can only use pure non-carbonated bottled or cooled boiled water. Other liquids (compote, tea, juice, etc.) cannot be used for washing and dissolving Supraks tablets.
Supraks Solutab tablets can be taken regardless of the meal – that is, at any convenient time.
The dosage of Suprax Solutab is the same for the treatment of various diseases, and is caused only by the age and weight of the human body. Thus, adults over 18 years old and children of any age with a body weight of more than 50 kg should take Supraks Solutab 400 mg (1 tablet) once a day, or 200 mg (1/2 tablets) twice a day. Children weighing 25-50 kg, regardless of their age, should take Supraks Solutab 200 mg (1/2 tablet) once a day. Adults over 18 years old, if their body weight is less than 50 kg, should still take the drug in the adult dosage, that is, 400 mg (1 tablet) once a day, or 200 mg (1/2 tablet) two times times a day.
Children and adults suffering from kidney disease, in which creatinine clearance (CC) is more than 60 ml / min, should take Supraks in usual dosages, according to age and body weight. People who are on hemodialysis or have kidney problems with creatinine clearance (CK) of 21 – 60 ml / min should take Suprax in suspension, as they need to reduce the age-appropriate dosage by 25%, and this cannot be done accurately when using tablets . People who are on peritoneal dialysis or suffering from kidney disease with QA less than 20 ml / min can take Suprax in the form of tablets, reducing the age-appropriate dose by 50% – that is, by half.
The duration of the course of treatment with Suprax Solutab is determined by the nature and localization of the infectious-inflammatory process, and is as follows:
- Infections of the respiratory tract and upper respiratory tract – the duration of the course of therapy is 7-14 days
- Tonsillopharyngitis caused by Streptococcus pyogenes – the duration of the course of therapy should be at least 10 days
- Uncomplicated gonorrhea – Suprax Solutab is taken only once at a dose of 400 mg (1 tablet)
- Uncomplicated infections of the lower urinary tract (urethritis) in women – the duration of the course of therapy is 3-7 days
- Uncomplicated infections of the upper urinary tract (pyelonephritis, cystitis) in women – the duration of the course of therapy is 14 days
- Uncomplicated infections of the lower and upper urinary tract in men – the duration of treatment is 1 – 2 weeks.
In general, to determine the duration of a course of therapy, it is recommended to use the following rule: tablets should be taken within 1 to 2 days after the disappearance of symptoms of infection and / or the normalization of body temperature.
Tablets, suspension and capsules can be taken regardless of the meal.
For people on hemodialysis or suffering from impaired kidney function with creatinine clearance (QC) of less than 60 ml / min, Suprax should be taken in the form of a suspension or dispersible tablets. Suprax capsules are prohibited for people on hemodialysis, peritoneal dialysis, or suffering from kidney problems with a CC of less than 60 ml / min.
With prolonged use of Suprax (longer than 15 days), intestinal dysbiosis is possible and, consequently, excessive growth of Clostridium difficile, which provokes severe antibiotic-associated diarrhea and pseudomembranous colitis. With the development of diarrhea and signs of colitis, you should stop taking Supraksa and consult a doctor. Usually, mild forms of antibiotic-associated diarrhea disappear after Supraksa is canceled. But if the diarrhea is severe, then, in addition to drug withdrawal, corrective treatment is prescribed, for example, Vancomycin intake of 250 mg 4 times a day. It should be remembered that in case of diarrhea and pseudomembranous colitis, it is impossible to use drugs that inhibit the passage of contents through the intestines (Loperamide, Imodium).
People who have suffered from allergic reactions to penicillin antibiotics in the past may also be allergic to Suprax. If a person has Lyell’s syndrome, Stevens-Johnson syndrome or DRESS syndrome as an allergic reaction, you should immediately stop taking Suprax and consult a doctor as soon as possible.
In addition, you should stop taking Suprax and immediately go to the hospital if acute renal failure or hemolytic anemia has developed, since isolated cases of death from hemolytic anemia caused by other cephalosporins antibiotics are described. If Supraks provoked hemolytic anemia, then in the future one should refrain from using antibiotics of the cephalosporins group, as the organism can react to the development of anemia again on any drug of this class. You should also not start taking Suprax if a person has had an episode of hemolytic anemia in the past in response to the use of antibiotics of the cephalosporins group.
During the period of Supraxa use, a positive direct Coombs reaction and a false positive urine response to glucose are possible. These tests during the reception of Supraks is better not to pass, because they are not accurate.
People with diabetes should remember that the suspension contains sucrose in the amount of 15 g per 20 ml.
When using Supraksa in combination with Polymyxin B, Colistin, loop diuretics (Furosemide, Torasemide, Etacrynic acid, etc.) and aminoglycoside antibiotics (Gentamicin, Tobramycin, Amikacin, etc.) should monitor kidney function.
After prolonged use of Supraks, the state of the hematopoietic system should be monitored.
Use during pregnancy and breastfeeding
In pregnancy, Suprax can only be used if the intended benefit to the woman exceeds all possible risks to the fetus. In practice, cephalosporin antibiotics are often prescribed to pregnant women, since they are relatively safe compared to other antibacterial drugs.
Suprax is contraindicated during breastfeeding. Therefore, if a nursing woman needs to take the drug, then at the time of treatment, the baby should be weaned from the breast and transferred to artificial feeding. A day after taking the last dose of Supraksa, you can return to breastfeeding the baby again.
Suprax for children
Children younger than 12 years old can be given Suprax only in the form of tablets or suspensions. Supraks capsules are permissible for use only for children over 12 years old with a body weight of at least 50 kg. This means that the capsules can not be taken by children, even if they are 12 years old, but their body weight is less than 50 kg.
Supraks tablets are approved for use for children with a body weight of at least 25 kg. This means that, regardless of the child’s age, if his weight is 25 kg or more, he can be given Suprax Solutab in the form of dispersible tablets.
Suspension Supraks can be used for children from the age of 6 months. This dosage form is optimal for children under 12 years of age. Therefore, doctors recommend giving the drug to children in the form of a suspension, preferring it to tablets and capsules.
Children under the age of 6 months should be allowed to give Suprax in the form of a suspension only under the supervision of a physician, if it is not possible to replace this antibiotic with another, safer for the infant.
Influence on ability to operate mechanisms
Since Suprax can cause side effects from the nervous system (dizziness, tinnitus, etc.), it has a negative effect on psychomotor activity and the ability to control mechanisms. Therefore, during the entire period of use of the drug should refrain from any activities that require a high reaction rate and concentration.
Overdose of Suprax in any dosage form is possible, and is manifested by increased severity of side effects (except for allergic reactions). In case of overdose, wash the stomach, take a sorbent (activated carbon, polyphepan, polysorb, etc.) and then, if necessary, carry out symptomatic therapy in resuscitation, aimed at maintaining the normal functioning of vital organs and systems. Symptomatic therapy may include the use of glucocorticosteroids (Dexamethasone, Prednisolone, etc.), adrenaline (epinephrine), norepinephrine (norepinephrine), dopamine, as well as oxygen therapy, transfusion of various solutions and artificial ventilation of the lungs.
In case of overdose with Suprax, there is no need to perform peritoneal or hemodialysis, since these methods do not accelerate the excretion of the drug from the body.
Interaction with other drugs
Simultaneous use with canalicular secretion blockers (Allopurinol, Probenecid, diuretics (Furosemide, Etacrynic acid, Tobrasemid, etc.), penicillin antibiotics (Amoxicillin, Ampicillin, etc.), Phenilbutazone, etc.), is in the case, in the case, in the back of the room, in the back of the back of the body, in the back of the back of the body, in the skin, in the case, in the case, in the back of the body, in the case, in the case, in the case, in the case, in the same line; may provoke an overdose of the latter.
Suprax increases the concentration of carbamazepine in the blood while using these drugs.
Suprax reduces the value of the prothrombin index, thereby enhancing the effects of indirect anticoagulants (for example, Warfarin). Therefore, Suprax in combination with anticoagulants should be used with caution, constantly monitoring INR or PET, to prevent the development of bleeding.
Antacids containing aluminum or magnesium hydroxides (for example, Maalox, Almagel) should be taken 4 hours before or 1 to 2 hours after taking Supraks because they slow down and worsen the absorption of the antibiotic into the bloodstream. A Suprax, respectively, should be taken 1 to 2 hours before or 4 hours after antacids.
Admission Supraksa in combination with drugs that have a toxic effect on the kidneys (Polymyxin B, Kolistin, aminoglycoside antibiotics (Gentamicin, Tobramycin, etc.), Viomitsin and others), as well as diuretics (Furosemide, Etakrinova acid, etc.), increases the risk of kidney problems.
Suprax may reduce the effectiveness of oral contraceptives. Therefore, during the period of use and during the week after completion of therapy with Suprax, in addition to oral contraceptives, use barrier methods of protection from pregnancy (female, male condoms, caps, etc.).
Various dosage forms of Suprax (dispersible tablets, capsules and oral suspension) can cause the following side effects from various organs and systems:
1. Allergic reactions:
- Redness of the skin (skin flushing)
- Itchy skin
- Fever (high body temperature)
- Eosinophilia (the number of eosinophils in the blood is more than normal)
- Anaphylactic shock
- DRESS syndrome
- Lyell syndrome (toxic epidermal necrolysis)
- Erythema multiforme exudative (Stevens-Johnson syndrome)
- Serum-like syndrome.
2. Digestive system:
- Dry mouth
- Diarrhea or constipation
- Flatulence (enhanced gas)
- Stomach ache
- Candidiasis of the digestive tract (candidiasis of the intestine, stomach, esophagus, etc.)
- Pseudomembranous colitis.
3Liverand biliary system:
- Jaundice (yellowing of the skin, sclera of the eyes and mucous membranes)
- Increased blood bilirubin (hyperbilirubinemia)
- Alkaline phosphatase activity increase
- Increased liver transaminase activity (AsAT and AlAT).
4. Blood and blood system:
- Leukopenia (decrease in the total number of leukocytes in the blood below the norm)
- Neutropenia (decrease in the number of neutrophils in the blood below the norm)
- Thrombocytopenia (decrease in the number of platelets in the blood below the norm)
- Pancytopenia (decrease in the total number of erythrocytes, leukocytes and platelets in the blood)
- Blood coagulation disorder and related bleeding (prolongation of prothrombin time)
- Agranulocytosis (complete disappearance of basophils, eosinophils, neutrophils from the blood)
- Hemolytic anemia.
5. Urinary system:
- Interstitial nephritis
- Increased blood creatinine (creatininemia)
- Increased blood urea (uremia)
- Hematuria (appearance of blood in the urine)
- Acute renal failure.
6. Nervous system:
- Dysphoria (bad mood)
- Noise in ears
- Facial swelling
- Vaginal itching
- Hypovitaminosis V.
With the development of Lyell Suprax syndrome should be immediately canceled and consult a doctor as a matter of urgency.
Currently, in the domestic pharmaceutical market, Supraksa has two types of analogues – these are preparations-synonyms and, in fact, analogues. Supraxas synonyms are drugs that also contain cefixime as the active ingredient. Actually analogs are drugs that contain not an active substance, like Supraks, but have the most similar spectrum of therapeutic action. This means that antibiotics belonging to the cephalosporins group (to which Supraks himself belongs) are analogues of Suprax.
The following drugs are synonymous with Supraksa:
- Ixim Lupine powder for oral suspension
- Panzeph granules for the preparation of suspensions for oral administration, tablets
- Cemidexor tablets
- Ceforal Solutab tablets are dispersible.
The following antibiotics are analogues of Supraksa:
- Hazaran powder for solution for injection
- Axone powder for solution for injection
- Buckperazon powder for solution for injection
- Bestum powder for solution for injection
- Betasporina powder for solution for injection
- Biotriaxone powder for solution for injection
- Broadsef-S powder for solution for injection
- Vice powder for solution for injection
- Dardum powder for solution for injection
- Intrataxi powder for solution for injection
- Ificef powder for solution for injection
- Kefotex powder for solution for injection
- Klafobrin powder for solution for injection
- Klaforan powder for solution for injection
- Lendacin powder for solution for injection and infusion
- Lifaxon powder for solution for injection
- Litoran powder for solution for injection
- Lorazidim powder for solution for injection
- Loraxon powder for solution for injection
- Medaxone powder for solution for injection
- Medocef powder for solution for injection
- Movigip powder for solution for injection
- Movoperiz powder for solution for injection
- Operaz powder for solution for injection
- Orzid powder for solution for injection
- Oritax powder for solution for injection
- Oritaim powder for solution for injection
- Oframaks powder for solution for injection
- Paktotsef powder for solution for injection
- Rezibelakta powder for solution for injection
- Roceferin powder for solution for injection
- Rocephin powder for solution for injection and infusion
- Sefotek tablets
- Spectracef tablets
- Stericheff powder for solution for injection
- Sulzonzef powder for solution for injection
- Sulmover powder for solution for injection
- Sulperazon powder for solution for injection
- Sulperacef powder for solution for injection
- Sultsef powder for solution for injection
- Sultsefazon powder for solution for injection
- Tax-o-bid powder for solution for injection
- Talcef powder for solution for injection
- Tarcefoxim powder for solution for injection
- Tercef powder for solution for injection
- Tezim powder for solution for injection
- Torocef powder for solution for injection
- Triaxone powder for solution for injection
- Fortazim powder for solution for injection
- Fortoferin powder for solution for injection
- Fortum powder for solution for injection
- Hison powder for solution for injection
- Cebanex powder for solution for injection
- Cedex Capsules and Powder for Suspension
- Tseperon J powder for solution for injection
- Cetax powder for solution for injection
- Cefabol powder for solution for injection
- Cefaxone powder for solution for injection
- Cefantral powder for solution for injection
- Cefatrin powder for solution for injection
- Cefzid powder for solution for injection
- Cefsoxim J powder for solution for injection
- Cefobid powder for solution for injection
- Cefogram powder for solution for injection
- Cefoperabol powder for solution for injection
- Cefoperazone powder for solution for injection
- Cefuperus powder for solution for injection
- Cefosin powder for solution for injection
- Cefotaxime powder for solution for injection
- Cefpar and Cefpar SV powder for solution for injection
- Cefson powder for solution for injection
- Ceftazidime powder for solution for injection
- Ceftidine powder for solution for injection
- Ceftriabol powder for solution for injection
- Ceftriaxone powder for solution for injection.
Supraks – cheaper analogues
Most of the reviews about Supraks (from 70 to 80%) are positive, due to their high efficacy for the treatment of severe, protracted infectious diseases of the respiratory and urogenital systems, as well as ENT organs in children and adults.
The reviews indicate that the antibiotic helped with tracheitis, bronchitis, otitis media, sinusitis, purulent tonsillitis, pyelonephritis, pharyngitis and a number of other infections of the respiratory, urinary and biliary tract, and genitals in children and adults. Suprax proved to be effective in severe and prolonged course of these diseases, when other drugs (including other antibiotics) and treatment methods were ineffective.
In addition to high efficiency, according to the people who used it, the antibiotic also has other positive characteristics: the possibility of use in young children and ease of use. In addition, separately in reviews as a plus Supraksa noted that it can be taken orally, which avoids the painful injections of other antibiotics that are effective for the treatment of bacterial infections of the respiratory and urinary organs.
The disadvantages of Supraks include its high cost, the risk of developing severe allergies, as well as the short shelf life of the finished diluted suspension.
Negative reviews of Suprax are due either to its ineffectiveness in any particular case or to the development of a severe allergic reaction to the drug.
Supraks (Supraks suspension, Supraks 400, Supraks tablets) – the price
Author: Nasedkina A.K. Specialist in conducting research on biomedical problems.